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Controlled uncoupling with modified dinitrophenol analogs (e.g., DNP-Mito) reduced mtROS by 65% while maintaining ATP synthesis in hypertensive rat models (Kotova and Antonenko, 2022)

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An important feature of ROA is that this technique is well-suited to measure the extent of polyproline II (PPII) conformation (Smyth et al., 2001), which could be dominant in unfolded peptides and proteins (Shi et al., 2002)